Introduction: Warts are benign proliferation of the skin and mucosa caused by various strains of double stranded DNA human papilloma virus (HPV)(2). Auto-implantation of wart is a novel, simple procedure which treats wart by stimulation of cell mediated immune response to clear HPV virus from the body(3). Aim & Objectives: To study the role of auto-implantation therapy in cutaneous viral warts and to study the efficacy and safety of auto-implantation therapy in cutaneous viral warts. Material & Methods: Total 60 patients [30 case and 30 control] of both sexes were included after randomization in the study. Results: Total 29 cases out of 30 completed the treatment, 5 [17%] shows no response, 6 [20%] shows partial response and 18 [62%] shows complete response. Conclusion: Autologous auto-implantation is an easy, minimally invasive technique, which helps in induction of an adequate immune response leading to resolution of warts.