Changing life style, lack of exercise, fast foods, improper unbalanced diet, and sedentary lifestyle has lead to the outbreak of Life style disorders. Among them Diabetes mellitus is an endocrinal and/or metabolic disorder with an increasing global prevalence and incidence. Bio-purification (Panchkarma) therapy is well known procedure for its Excellency to cure and prevent the disease from the root cause. Due to lots of benefits of Panchkarma i.e. Shodhana Karma (Bio-purificatory therapy) it has grabbed a worldwide attention. Tough it has wide range of applicability but mainly indicated in Chronic disorders like Diabetes mellitus (Madhumeha). Virechana Karma (Therapeutic purgation) is one such treatment module of purification (Shodhana) in Diabetes Mellitus. It could be used in all diseases of endocrinal disturbance. Holistic approach of Ayurveda in regard to preventive, promotive and purificative measures provide better health in such diseases. Aim: To establish role of Virechana Karma in the management of Diabetes Mellitus. Materials and methods: All the PG and PhD thesis on Diabetes mellitus were referred for the study. Conclusion: On observation of clinical data it can be concluded that Virechana Karma is effective clinically and statistically in prevention and management of Diabetes mellitus.