Case Report: A 43 year old HIV– 2 positive patient came with passage of semisolid stool 5–6 times a day since 3 months, abdominal discomfort since 3 months. Patient has CD4 count 280 & on ART treatment consisting of Tenofovir, Lamivudine, Atazar & Retonavir. Initially he was treated with Ornidazole & Ofloxacin combination tablet for 5 days still the symptoms prevailed. Deworming with Albendazole was also done still the frequency of passage of stool remained the same.Microscopy, saline preparation showed plenty of giant budding yeast cells (3–4 μm x 5 –8 μm) in every high power field. Pseudohyphae were predominant. Ova, cysts, trophozoites were not seen; nor were there any red blood cells, pus cells or macrophages. On Corn Meal agar with tween 80 at 25?C after 72 hours showed presence of abundant pseudomycelium, mostly consisting of branched chains of elongate cells in more or less Christmas tree–like arrangement. Proving it to be Candida parapsilosis.