Purpose: To study the effect of Platelet derived growth factor (rhPDGF)in healing of Diabetic foot Ulcers in study group. Method: The present study was a randomized controlled Study. A Total of 50 patients were assigned. Control group patients (30) were treated with conventional dressing and study group patients(20) were treated with rh-PDGF dressing. Results: The study group patients showed wound healing in 30% of patients against control group of 16.66%. Mean duration of time taken for complete ulcer closure in study group is 41.5 days against 54.8 days in controls. Total wound surface area reduction after 8 weeks is 71.54% in study group compared to 35.72% in control group. Ulcers with ≥ 50% surface area reduction in study group were 70% compared to 43.3% in control group. Conclusion: Topical application of 7µg/cm2 of rh-PDGF once daily significantly increases incidence of wound healing in chronic diabetic foot ulcers.