<?xml version="1.0" encoding="UTF-8"?><article>
	<front>
		<journal-meta>
			<journal-id journal-id-type="publisher">GJRA</journal-id>
			<journal-title>GJRA - Global Journal For Research Analysis</journal-title>
			<issn pub-type="ppub">2250 - 1991</issn>
			<publisher>
				<publisher-name>Indian Society for Health and Advanced Research</publisher-name>
			</publisher>
		</journal-meta>
		<article-meta>
			<article-id pub-id-type="other">gjra-8-8-12412</article-id>
			<article-categories>
				<subj-group>
					<subject>Original Research Paper</subject>
				</subj-group>
			</article-categories>
			<title-group>
				<article-title>Comparison of intrathecal Bupivacaine and Bupivacaine with Butorphanol for post-operative analgesia in patients undergoing lower abdominal surgery</article-title>
			</title-group>
			<contrib-group><contrib contrib-type="author">
						<name>
							<surname>Chaitali</surname>
							<given-names>Biswas</given-names>
							<prefix>Dr.</prefix>
						</name>
						<xref ref-type="aff" rid="aff000">
							<sup></sup>
						</xref>
						</contrib><contrib contrib-type="author">
						<name>
							<surname>Dr.</surname>
							<given-names>Dhurjoti Prosad Bhattacharjee</given-names>
							<prefix>Dr.</prefix>
						</name>
						<xref ref-type="aff" rid="aff002">
							<sup></sup>
						</xref>
						</contrib></contrib-group><pub-date pub-type="ppub">
				<month>August</month>
				<year>2019</year>
			</pub-date>
			<volume>8</volume>
			<issue>8</issue>
			<fpage>01</fpage>
			<lpage>02</lpage>
			<abstract>
				<title>ABSTRACT</title>
				<p>Background and Aim
Opioids, like butorphanol, have been widely used for providing pain relief postoperatively and the advantages of neuraxial narcotics over systemic narcotics are well established. When compared to local anaesthetics, they offer good analgesia while allowing early ambulation of the patient by sparing sympathetic and motor nerves. The aim of the study was to compare the safety and efficacy of anaesthesia and analgesia of intrathecal bupivacaine-butorphanol mixture with intrathecal bupivacaine alone.
Methods: 	
This randomized prospective double-blind active-control study was performed on 60 female patients, aged between 18 and 60 years of ASA physical status I and II  undergoing various elective lower abdominal  surgeries under spinal anaesthesia. Patients were randomized in two groups, with 30 patients in each group. Patients in the Group B  received 3ml (15mg) of 0.5% hyperbaric Bupivacaine plus 25 microgram of Butorphanol (0.25 ml) making a total volume of 3.25 ml and Group C  received 3ml (15mg) of 0.5% hyperbaric Bupivacaine  plus 0.25 ml of normal saline making a total volume of 3.25 ml intrathecally. Onset and duration of analgesia were recorded. The efficacy of analgesia was recorded based on VAS score. Side effects, time of recovery also were noted. 

 Results and observations:
The two groups were comparable regarding the demographic profile.  The onset of sensory block was delayed in group C (3.4 &amp;plusmn; 1.3 min) when compared to group B (2.73 &amp;plusmn; 0.78 min). The duration of sensory block as well as motor block was prolonged in butorphanol group (376.53 &amp;plusmn; 10.32 mins) and (149.47 &amp;plusmn; 6.76 min) respectively as compared to bupivacaine group (144.37 &amp;plusmn; 25.32 min) and (135.63 &amp;plusmn; 30.74 min) respectively. Both the findings were significant. Butorphanol provided a significantly longer duration of postoperative analgesia (432.60&amp;plusmn; 12.04 vs 140.03 &amp;plusmn; 26.46 mins). No drug related side effects were observed in either group.
Conclusions:
 Intrathecal bupivacaine-butorphanol mixture provides longer duration of sensory blockade and superior analgesia than intrathecal bupivacaine alone.
</p>
			</abstract>			
			<counts>
				<ref-count count="7"/>
				<page-count count="2"/>
			</counts>
		</article-meta>
	</front>
</article>