Background : Dilatation and curettage (D&C) is the gold standard for endometrial sampling. We compared endometrial sampling by pipelle curette with conventional dilatation and curettage (D&C) in patients with abnormal uterine bleeding. The aim and objectives of the study was to determine the reliability of pipelle device in acquiring an adequate & representative endometrial sample compared to D&C and to compare the result of histopathological diagnosis of pipelle sampling with D&C. Materials and Methods: A cross-sectional study was done at SKIMS soura , Srinagar , between 11/11/2017 to 10/11/2018. 100 cases of abnormal uterine bleeding (AUB) attending the outpatient clinic in the department of obstetrics & gynecology were included in the study. Endometrial sampling with pipelle device was performed in 100 patients followed by formal D&C. Results: For obtaining the endometrial sample the sensitivity of pipelle sampling was 97% and the specificity was 100% when compared with D&C sampling. The diagnosis made by the HPE report by the sample obtained from pipelle had shown a very high sensitivity, specificity, positive predictive value and negative predictive value, except for the diagnosis of endometrial polyp which the pipelle sample was not able to detect. Conclusions: The endometrial sampling using Pipelle is a safe, accurate, cost effective, outpatient procedure, which avoids general anesthesia and has a high sensitivity and specificity for detection of endometrial hyperplasia and endometrial malignancy.