Background: keloid is a benign overgrowth of fibrotic tissue and are aesthetically unacceptable to the patients. Management is difficult and pose a challenge for physicians. This study compares the efficacy and safety of intralesional triamcinolone acetonide, intralesional 5-fluorouracil and combination of both in management of keloids. Method: Total 60 patients, randomly divided into three groups: A, B, C were subjected to intralesional Triamcinolone acetonide, 5- Fluorouracil and their combination respectively, every 3weeks for 18 weeks and assessed with Vancouver Scoring Scale. Results: Improvement seen in all parameters, maximum with combination of triamcinolone and 5-fluorouracil. Major side effects were hypopigmentation with intralesional triamcinolone; pain and hyperpigmentation with intralesional 5-fluorouracil and mild pain with combination of two. Conclusion: Combination of 5-fluorouracil and triamcinolone acetonide seemed to be more effective with lesser side effects than the other two.