The appearance of epidemics is not something new in the history of humanity, but in recent years we are witnessing epidemic outbreaks, many of them by viruses, causing social alarm. Following the SARS-CoV and MERS-CoV epidemics, strategies were established in China for the timely identification of emerging and reemerging viruses. 1 The new Coronavirus, cataloged as SARS-CoV-2 and its disease COVID-19, has currently caused a pandemic, where its behavior is still uncertain. The clinical-prognostic factors of COVID-19 infection have led us to present this clinical case, which meets several criteria for severity, which culminated in its death. Objective: Identify clinical prognostic factors for severe disease and mortality in COVID-19 patients early in order to provide adequate therapy according to the case of each patient and avoid poor prognosis. Method: This is a retrospective study, clinical prognostic factors for severe disease and mortality in COVID-19 patients, emphasizing its clinical, imaging and laboratory examination analysis characteristics. Conclusión: COVID-19 disease, caused by the so-called severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), produces respiratory disease, which can progress to a form of severe pneumonia in 10 to 15% of patients, and continue to a state of critical illness, characterized by the presence of acute respiratory distress syndrome (ARDS) and multisystemic organ failure (FOM). Several determinants have been mentioned such as age, comorbidity, LDH, CRP, and elevated D-Dimer to fit in a serious disease with high mortality, which is why in the present clinical case highlights risk factors for serious disease and mortality.