<p> To assess the treatment outcome in all forms of CNS TB with DOTS regimen, in a tertiary care Medical college Hospital. Methodology: All newly diagnosed CNS tuberculosis patients (both adult and pediatric) registered in Medical College Hospital from January 2015 to June 2015 were included in the study. DOTS treatment was given as per RNTCP guidelines. Treatment outcome and other data were collected from the TB register maintained in the Thoracic department. Results: A total of 61 patients with CNS TB were included in the study, of whom 43 patients (80%) completed 6 months of ATT, 4 (7%) defaulted and 11 (18%) died. Out of 43, 24 (55%) patients were asymptomatic at the end of 9 months of treatment. Conclusion: Treatment for CNS TB under RNTCP is effective, but still mortality and morbidity is significantly high. Hence early diagnosis and appropriate treatment is necessary.</p>