<p> Introduction: Infantile hypertrophic pyloric stenosis (IHPS) is the most common cause of gastric outlet obstruction in infancy. It is treated surgically by pyloromyotomy. Medical management with atropine sulphate has been reappraised as an option for IHPS. Patients and Methods: Our study population consisted of 4 patients of IHPS admitted in the hospital. The parents of these patients had refused surgical treatment. All four of them were treated medically using atropine. Results: All four patients were successfully managed with atropine. We evaluated ultrasonography findings of these patients before and after medical management and documented improvement. Vomiting ceased and significant weight gain was seen in all four patients. There were no complications noted. Conclusion: This study shows there is definite role of atropine in management of IHPS in special situations.</p>