<p> Introduction: This study was undertaken to compare and evaluate the analgesic efficacy between levobupuvacaine and levobupivacaine - fentanyl combination for post operative pain relief after arthroscopic knee surgery . Aims to compare total rescue analgesia requirement in first 24 hrs in these two groups and compare the adverse effects. Methodology: 66 adult patients randomly allocated in two groups to received 20 ml 0.5% levobupivacaine with 1ml normal saline and 20ml 0.5% levobupivacaine with 1ml fentanyl. At the end of arthroscopic procedure done under general anesthesia before port closure, study drugs were administered. Intramuscular Diclofenac 75mg uses as rescue analgesic when VAS>4. Results: Time of rescue analgesia in Group A was 335.75±30.39 minutes compared to Group B 373.81±25.70 minutes. Total rescue analgesia in Group A were 1.687±0.4709 compared to Group B;1.39±0.4961. No adverse effects observed . Conclusion: Intra-articular levobupivacaine with fentanyl is more efficacious than levobupivacaine alone.</p>