<p> Health care associated infections are becoming challenging day by day. Just to perceive the interplay of underlying epidemiological factors in current scenario this prospective study was undertaken for a period of ten months in associated hospital of LN Medical College, Bhopal. Various hospital acquired infection’s related data was evaluated in separate time periods. Over a period of 10 months catheter-associated urinary tract infections (CAUTI), central-line-associated blood stream infections (CLABSI), ventilator-associated pneumonias (VAP) related rates were revealed as 12.59, 12.4 & 16.15 respectively per thousand device days. Surgical site infection (SSI) rates were found to be fluctuating in-between 0.792% to 10.5%. It was concluded that in order to bring down these rates bundled intervention based surveillance checklists are to be followed along with other disinfection & sterilization related measures. Also root cause analysis approach has been recommended to gain control over the problem</p>