<p> Several diseases such as liver diseases are caused due to free radicals formation, which leads to decrease in antioxidant enzymes in the body. Carbontetrachloride is metabolized in the liver to generate free radicals, which react with cellular lipids and proteins, eventually leading to cell death. The present work is carried out to investigate the hepatoprotective effect of Artemisia dracunculus L leaves against carbon tetrachloride induce liver toxication in rats. Carbon tetrachloride treatment group showed significantly elevated the alanine aminotransferase, aspartate aminotransferase, alkaline phosphatie.. Ethanolic leaves extract of Artemisia dracunculus L (250 and 500 mg/kg) significantly restored the carbon tetrachloride-induced alterations in the biochemical and cellular constituents of blood. The hepatoprotective effect of Artemisia dracunculus L was also confirmed by the histopathological examination of liver tissue.</p>