<p> The present communication describes a rapid, precise and accurate RP-HPLC method for the simultaneous quantiöcation of metformin and repaglinide in bulk and tablet dosage forms. Chromatographic separation of the selected drugs was carried out on Phenomenex C18 analytical column (250 mm x 4.6 mm, 5 μ particle size). An isocratic elution system was developed using 0.1M ammonium acetate: acetonitrile [50:50 v/v]. The pH of the mobile was adjusted to 4.2 with orthophosphoric acid. The elution of the drugs was achieved with a øow rate of 1.0 ml/min. Detection was by UV absorbance at a wavelength of 254 nm. The detector response was linear in the concentration of 500-1500 µg/ml and 2-6 µg/ml for metformin and repaglinide, respectively. The method was validated following ICH guidelines. All the parameters of validation were found in the acceptance range.</p>