<p> <span style="text-align: justify; vertical-align: baseline;">A new series of some analogues of 6,8-dibromoquinazolin-4(3<i>H</i>)-ones <b>6</b></span><b style="text-align: justify;"><sub>1-12</sub></b><span style="text-align: justify; vertical-align: baseline;"> have been synthesized by the cyclisation of acrylamide <b>5</b></span><b style="text-align: justify;"><sub>1-12</sub></b><b style="text-align: justify;"><span style="vertical-align:
baseline"> </span></b><span style="text-align: justify; vertical-align: baseline;">with<b> </b>hydrazine hydrate. The overall reaction was based catalysed conventional multistep process. The title compounds have been characterized by spectral data IR, </span><span style="text-align: justify;">1</span><span style="text-align: justify; vertical-align: baseline;">H NMR, </span><span style="text-align: justify;">13</span><span style="text-align: justify; vertical-align: baseline;">C NMR and elemental analysis. All the synthesized compounds were screened for antibacterial and fungicidal activity <i>In Vitro</i> by disc diffusion method and strength compare with standard drug.      </span></p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><span style="vertical-align:
baseline"> <br /> <o:p></o:p></span></p>