<p class="MsoNormal" style="margin-bottom:12.0pt;line-height:200%;mso-pagination:
none;mso-layout-grid-align:none;text-autospace:none"><b><span lang="EN-GB" style="mso-bidi-font-family:Times;color:black">Background</span></b><span lang="EN-GB" style="mso-bidi-font-family:Times;color:black;mso-bidi-font-weight:
bold">:</span><span lang="EN-GB" style="mso-fareast-font-family:"Times New Roman";
mso-bidi-font-family:"Times New Roman";color:#2A2A2A;background:white;
mso-fareast-language:EN-GB">Endometrial cancer is the most common gynaecological malignancy affecting women in developed countries and the second most common gynaecological malignancy world-wide.</span><span lang="EN-GB" style="color:black;mso-themecolor:text1">The apoptotic index, defined as the percentage of morphologically identified apoptotic cells per 100 non apoptotic cells</span><span lang="EN-GB" style="mso-bidi-font-family:Times;color:black;
mso-bidi-font-weight:bold">.</span><span lang="EN-GB" style="mso-bidi-font-family:
"Times New Roman";mso-fareast-language:EN-GB">Apoptosis is observed at increasing levels in the hyperplasia, atypia, adenocarcinoma sequence</span><b><span lang="EN-GB" style="mso-bidi-font-family:Times;color:black">. Methods</span></b><span lang="EN-GB" style="mso-bidi-font-family:Times;color:black;mso-bidi-font-weight:
bold">: </span><span lang="EN-GB" style="mso-bidi-font-family:"Times New Roman";
color:black">In all hysterectomy cases, histological findings and apoptotic index was noted. The cases were divided into five categories. Mean apoptotic index was calculated in each category and comparison was done.</span><b><span lang="EN-GB" style="mso-bidi-font-family:Times;color:black">Results:</span></b><span lang="EN-GB" style="mso-bidi-font-family:"Times New Roman";color:black">Edometrialcarcinoma had significantly higher apoptotic index than other categories (p-value =0.000). An increasing mean apoptotic index was noted in complex hyperplasia categories than in simple hyperplasia ones. </span><b><span lang="EN-GB" style="mso-bidi-font-family:
Times;color:black">Conclusion</span></b><span lang="EN-GB" style="mso-bidi-font-family:
Times;color:black;mso-bidi-font-weight:bold">: Apoptotic index gradually increases with increasing complexicity in endometrium.<o:p></o:p></span></p>