<p class="MsoNormalCxSpFirst" style="text-align:justify;line-height:normal"><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:12.0pt;
font-family:"Times New Roman","serif"">Introduction:</span></b><span lang="IN" style="font-size:12.0pt;font-family:"Times New Roman","serif"">Gouty arthritis is a metabolic disease associated with a high diet of purines and alcohol consumption. Monosodium urate crystal accumulation (MSU) in joints and soft tissues is the main trigger of inflammation in gouty arthritis. This disease can adversely affect the quality of life of the patient. Increased levels of uric acid in the blood (hyperuricemia) is the main cause of gouty arthritis. One of the medicinal plants is sidaguri (<i style="mso-bidi-font-style:normal">Sida rhombifolia L</i>), <span style="color:black">has been known to have the potential of antigout and anti-inflammatory activities by inhibiting nitric oxide.</span><o:p></o:p></span></p> <p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:12.0pt;
font-family:"Times New Roman","serif"">Method:</span></b><span style="font-size:12.0pt;font-family:"Times New Roman","serif";mso-ansi-language:
EN-US">This randomized controlled trial was conducted in Adam Malik Hospital </span><span lang="IN" style="font-size:12.0pt;font-family:"Times New Roman","serif";
color:black">and Prof. Dr. Boloni Hospital Medan from April</span><span style="font-size:12.0pt;font-family:"Times New Roman","serif";color:black;
mso-ansi-language:EN-US">- </span><span lang="IN" style="font-size:12.0pt;
font-family:"Times New Roman","serif";color:black">October 2018</span><span style="font-size:12.0pt;font-family:"Times New Roman","serif";color:black;
mso-ansi-language:EN-US">. </span><span lang="IN" style="font-size:12.0pt;
font-family:"Times New Roman","serif";color:black">Patients </span><span style="font-size:12.0pt;font-family:"Times New Roman","serif";color:black;
mso-ansi-language:EN-US">randomized </span><span lang="IN" style="font-size:12.0pt;
font-family:"Times New Roman","serif";color:black">to receive Sidaguri extract (<i>Sida Rhombifolia</i><i style="mso-bidi-font-style:normal"> L</i>) and meloxicam or placebo andmeloxicamin a double-blind technique.</span><span style="font-size:12.0pt;font-family:"Times New Roman","serif";color:black;
mso-ansi-language:EN-US">Sample size of e</span><span lang="IN" style="font-size:
12.0pt;font-family:"Times New Roman","serif";color:black">ach of group was 20 patients.Data were statistically </span><span lang="IN" style="font-size:12.0pt;font-family:
"Times New Roman","serif"">analyzed.<o:p></o:p></span></p> <p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:12.0pt;
font-family:"Times New Roman","serif"">Result:</span></b><span style="font-size:12.0pt;font-family:"Times New Roman","serif";mso-ansi-language:
EN-US">40 Gouty arthritis patients divided into 2 groups: Sidaguri group (20 patients) and Placebo group (20 patients). </span><span lang="IN" style="font-size:12.0pt;font-family:"Times New Roman","serif"">Based on the T-dependent test, </span><span style="font-size:12.0pt;font-family:"Times New Roman","serif";
mso-ansi-language:EN-US">there was </span><span lang="IN" style="font-size:12.0pt;
font-family:"Times New Roman","serif"">significant differences of uric acid and CRP</span><span style="font-size:12.0pt;font-family:"Times New Roman","serif";
mso-ansi-language:EN-US"> serum before and after treatment between Sidaguri group and Placebo group in Gouty arthritis patients (p=0.0001).</span><span lang="IN" style="font-size:12.0pt;font-family:"Times New Roman","serif""><o:p></o:p></span></p> <p class="MsoNormalCxSpMiddle" style="text-align:justify;line-height:normal"><b style="mso-bidi-font-weight:normal"><span lang="IN" style="font-size:12.0pt;
font-family:"Times New Roman","serif"">Conclusion:</span></b><span lang="IN" style="font-size:12.0pt;font-family:"Times New Roman","serif""> There was significant difference</span><span style="font-size:12.0pt;font-family:"Times New Roman","serif";
mso-ansi-language:EN-US">s</span><span lang="IN" style="font-size:12.0pt;
font-family:"Times New Roman","serif""> between uric acid levels and CRP before and after treatment of Sidaguri.<o:p></o:p></span></p>