<p> </p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><b style="mso-bidi-font-weight:normal"><span style="font-family:"Times New Roman","serif"">Background: </span></b><span style="font-family:"Times New Roman","serif"">To determine the effective volume of a combination of bupivacaine and lignocaine for supraclavicular brachial plexus block using ultrasonography (USG).<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><b style="mso-bidi-font-weight:normal"><span style="font-family:"Times New Roman","serif""><o:p> </o:p></span></b></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><b style="mso-bidi-font-weight:normal"><span style="font-family:"Times New Roman","serif"">Methods: </span></b><span style="font-family:"Times New Roman","serif";mso-fareast-font-family:
TimesNewRomanPSMT">This study is an intervention study to determine the minimum effective volume of a drug combination. </span><span style="font-family:"Times New Roman","serif"">The principle statistical method applied in this study is Staircase Up-down method as described by Dixon and Massey.<sup>(<a style="mso-endnote-id:edn1" href="file:///C:/Users/WWJ16/Desktop/ADMIN/GJRA/NOV/Word%20Numbring%20File/13.Saurabh%20Khurana.docx#_edn1" name="_ednref1" title=""><span class="MsoEndnoteReference"><span style="mso-special-character:footnote"><!--[if !supportFootnotes]--><span class="MsoEndnoteReference"><span style="font-size:12.0pt;font-family:"Times New Roman","serif";
mso-fareast-font-family:"MS Mincho";mso-fareast-theme-font:minor-fareast;
mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">[i]</span></span><!--[endif]--></span></span></a>)</sup> <b style="mso-bidi-font-weight:normal"><o:p></o:p></b></span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><b style="mso-bidi-font-weight:normal"><span style="font-family:"Times New Roman","serif""><o:p> </o:p></span></b></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><b style="mso-bidi-font-weight:normal"><span style="font-family:"Times New Roman","serif"">Results:</span></b><span style="font-family:"Times New Roman","serif""> By using the log transformation of the data of required volume and outcome as successful or unsuccessful we have calculated EV 50 = 11ml and EV 90 = 14ml.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph"><span style="font-family:"Times New Roman","serif""><o:p> </o:p></span></p> <p><b style="mso-bidi-font-weight:normal"><span style="font-size:12.0pt;
font-family:"Times New Roman","serif";mso-fareast-font-family:"MS Mincho";
mso-fareast-theme-font:minor-fareast;mso-ansi-language:EN-US;mso-fareast-language:
EN-US;mso-bidi-language:AR-SA">Conclusion:</span></b><span style="font-size:
12.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"MS Mincho";
mso-fareast-theme-font:minor-fareast;mso-ansi-language:EN-US;mso-fareast-language:
EN-US;mso-bidi-language:AR-SA"> Minimum Effective Volume in 90% individuals (MEV 90) for a combination of 0.25% bupivacaine and 1% lignocaine for ultrasound guided brachial plexus block via supraclavicular approach is 14ml.</span></p> <div style="mso-element:endnote-list"><!--[if !supportEndnotes]--><br clear="all" /> <div style="mso-element:endnote" id="edn1"> <p class="MsoEndnoteText" style="margin-left:.5in;text-align:justify;text-justify:
inter-ideograph;text-indent:-.5in"> </p> <p class="MsoEndnoteText" style="margin-left:.5in;text-align:justify;text-justify:
inter-ideograph;text-indent:-.5in"><span style="font-size:10.0pt;font-family:
"Times New Roman","serif""><o:p> </o:p></span></p> </div> </div>