ABSTRACT

GJRA

GJRA - Global Journal For Research Analysis

2250 - 1991

Indian Society for Health and Advanced Research

gjra-7-11-9788

Original Research Paper

Comparison the Effect of Combination Sambiloto Extract (Andrographis paniculata (Burm.f.) Nees) and Salam (Syzygium polyanthum (Wight) Walp) with Simvastatin on Apo-B Concentration in Dyslipidemia Patients

Sunata

Dr. Santi

Syafril

Dr.

November 2018

7 11 01 02 ABSTRACT

&nbsp; Background : Dyslipidemia is risk factor of cardiovascular disease and significantly correlated with increased Apo-B concentration. Simvastatin, a sintetic antidyslipidemic drug,can decreaseApo-B concentration. But long term use&nbsp; of sintetic drug may cause side effects, so that phytopharmaca is begin to reuse. Combination sambiloto extract and salam could decrease cholesterol, triglyceride, and proinflammatory cytokines. Aim of this study was to compare the effect of combination sambiloto extract and salam with simvastatin onApo-B concentration in dyslipidemic patients. Method : This clinical trial use prospective design. Study group (n = 15) and control group (n = 15) were choosen with double blind random sampling. Before and after 30 days theraphy, blood sample was taken. Data was analysed with SPSS, if p&lt; 0.05 was considered significant difference. Result: Before and after 30 days theraphy was there was insignificant increase of Apo-B in study group(106,93 + 17,56 VS 107,73 + 26,96) mg/dL; p = 0,463); meanwhile significant decrease&nbsp; was there in control group(117,46 + 27,13 vs 101,80 + 30,01) mg/dL; p = 0,001). Apo-B decrease of control group was biger than that of study group, but statistically insignificant (-0,80 + 33,42 vs 15,66 + 16,85) mg/dL; p = 0,0125).Conclusion: Combination sambiloto extract (Andrographis paniculata) and salam (Syzygium polyanthum)2 x @ 150 mg for 30 days not decreased Apo-B concentration than simvastatin 1 x 20 mg, with statistically insignificant.<o:p></o:p>