A ASSOCIATION OF ABNORMAL COAGULATION PROFILE AND LIVER ENZYMES WITH DENGUE INFECTION AND THEIR SIGNIFICANCE AS PREDICTORS OF ASSESSING SEVERITY OF DISEASE

Subramani Murugesan; Vinoj murugesan

Volume : X, Issue : IV, April - 2020

A ASSOCIATION OF ABNORMAL COAGULATION PROFILE AND LIVER ENZYMES WITH DENGUE INFECTION AND THEIR SIGNIFICANCE AS PREDICTORS OF ASSESSING SEVERITY OF DISEASE

Subramani Murugesan, Vinoj Murugesan

Abstract :

CONTEXT: Dengue fever is one of the most severe arthropod borne viral diseases in terms of human mortality and morbidity. The major cause of mortality is DHF/ DSS. There are multiple reasons for abnormal haemostasis such as vascular endothelial damage. Thrombopahty and coagulation abnormalities. Various studies have revealed significant abnormalities in the coagulation and inflammation systems in dengue fever. The imbalance between coagulation and fiinolysis may be used a prognostic marker AIM OF THE STUDY: • To assess the liver enzyme and coagulation profile alterations among dengue patients . • To follow up dengue patients over a period of 10 days and asses the progression of disease. • To asses correlation between the abnormal lab parameters and their significance as early predictors of fluid leakage and bleeding SETTINGS AND DESIGN: Analytical Case Control Study. MATERIALS AND METHODS: This The study will be conducted on 100 dengue patients admitted to GRH , Madurai during the study period of 12 months INCLUSION CRITERIA: • Patients presenting with fever from a dengue endemic • H/o headache , joint pain , nause , vomiting • lab confirmed dengue • positive tourniquet test EXCLUSION CRITERIA: • Patients with bleeding diathesis . • Patients on Anticoagulant therapy . • Alcoholics . • CLD patients A previously designed proforma was used to collect the demographic and clinical details of the patients. All the patients underwent detailed clinical evaluation, appropriate investigations, STATISTICAL ANALYSIS: One way ANOVA, Pearson correlation and Chi square test. RESULTS: 1) SGOT and SGPT elevation proved to be an early predictor in the progression of Dengue fever to Dengue Haemorrhagic fever 2) aPTT prolongation proved to be an even early predictor in the progression of Dengue to Dengue haemorrhagic fever and hence rapid intervention prevented the dreaded complications of dengue