A CASE CONTROL STUDY OF EVENT RELATED POTENTIAL P300 WAVE IN HEADACHE FREE PERIOD OF MIGRAINE PATIENTS AND HEALTHY CONTROL SUBJECT

Dr. Gopal Sharma; Dr. Abhishek Saini; Dr. Amitabh Dube

Volume : VIII, Issue : II, February - 2018

A CASE CONTROL STUDY OF EVENT RELATED POTENTIAL P300 WAVE IN HEADACHE FREE PERIOD OF MIGRAINE PATIENTS AND HEALTHY CONTROL SUBJECT

Dr. Gopal Sharma, Dr. Abhishek Saini, Dr. Amitabh Dube

Abstract :

Background: Chronic migraine patients sometimes complain regarding attention and memory during their long course of disease process. Migraine has a modifying impact sub – clinically on cognitive skills that have been evaluated by a battery of psychological questionnaire based investigative tools both in clinical settings and community. The purpose of this study is to evaluate neurocognitive functions in migraineurs in terms of neural dynamics of endogenous P300 wave ERP (Event Related Potential) component through assessing the amplitude and latency of P300 wave by auditory oddball task. This study establishes the potential role of P300 wave–form as an independent neuropsychological tool for a better appreciation of subclinical reduced cognitive profile with underlying dysfunctional neural dynamics in migraine patients.

Material and Methods: 30 migraine patients in age group of 18–35 year and 30 healthy sex and age matched healthy control subjects were recruited in this study. EEG was recorded to obtain time locked ERPs at Cz, Pz, C3, C4, T3 and T4 electrode sites using 10–20 international system and deploying auditory oddball paradigm during active counting task in migraineurs without aura during headache free period and healthy control subjects. The amplitudes and latencies of P300 wave during active counting task were compared in migraine patients and healthy control subjects using student’s t–test.

Result: The amplitude of P300 was observed to be lower in migraineurs indicating the subclinical reduced cognitive processing.

Conclusion: There is subclinical altered cognitive processing in migraine patients in interictal pain free period that might be related to subtle changes in biochemical, structural and/or functional activity in ain during course of disease process.