A Clinical study to compare the efficacy of intravenous Ondansetron with intravenous Lignocaine to alleviate pain on Propofol injection during general anaesthesia

Anurag Yadava; Pratiksha Dapkekar Pandhari

Volume : VII, Issue : XII, December - 2017

A Clinical study to compare the efficacy of intravenous Ondansetron with intravenous Lignocaine to alleviate pain on Propofol injection during general anaesthesia

Anurag Yadava, Pratiksha Dapkekar Pandhari

Abstract :

Background: Propofol has the significant disadvantage of causing pain or discomfort during intravenous (IV) injection. The aim of this prospective, observational study was to assess the efficacy of IV Ondansetron with IV lignocaine to alleviate pain on propofol injection during general anaesthesia. The primary objective was to compare the incidence and severity of pain during injection of propofol in ondansetron and lignocaine group and the secondary objective was to evaluate the hemodynamic stability and incidence of adverse effects in both the groups. Materials and Methods: 210 patients belonging to ASA grade I and II were assigned into 3 groups (70 each). Group L received 2 ml of 2% lignocaine, group O received 2 ml of Ondansetron and group N received 2 ml of 0.9% normal saline. Venous occlusion was done by compressing mid forearm with a tourniquet before injection, the study drugs were injected over 5 seconds and thereafter the occlusion was removed after 1 minute. The first calculated dose of propofol was then injected over 5 s. Patients were observed and asked 15 s later to rate immediately any sensation of pain in the arm and pain was scored on a four–point scale: 0 = no pain, 1 = mild pain, 2 = moderate pain, and 3 = severe pain. Paired Student’s t–test, chi–square test/one way ANOVA test were used to analyze results. Results: Pain was reduced significantly in group’L’ where majority (94.20%) experienced mild pain only as compared to other two groups and the difference was significant statistically (p<0.05). Conclusion: Pre–treatment with Lignocaine provides an effective method of reducing the incidence of pain on Propofol injection.