Volume : IX, Issue : VI, June - 2019

A STUDY ON CARBOPLATIN –PACLITAXEL INDUCED PERIPHERAL NEUROPATHY IN CANCER PATIENTS

Umamaheshwari. C, Shanthi. M

Abstract :

Background: Peripheral neuropathy is a common treatment related adverse effect and affects long term quality of life. AIM: To study the Carboplatin–Paclitaxel induced peripheral neuropathy in patients with lung or ovarian cancer. Methods: The study was carried out in the Department of Oncology, Government Rajaji Hospital, Madurai, after obtaining clearance from Institutional ethical committee, Government Rajaji Hospital, Madurai.Thirty newly diagnosed patients suffering from Lung or ovarian cancer attending Oncology department were selected. After satisfying inclusion and exclusion criteria,Patient received Injection Carboplatin AUC 6 and Injection Paclitaxel 175mg/m2 . Nerve conduction study was done to assess the peripheral neuropathy. It was done before starting the chemotherapy.Patients with grade 0 neuropathy were included for the study.Nerve conduction study was repeated after each cycle. The time taken to develop peripheral neuropathy was assessed using Cancer Institute – Common Toxicity Criteria version 3.0. The data were analyzed with SPSS statistical software package (Version 16.0 SPSS Inc., Chicago, USA ). Results: There is a statistically significant reduction in sensory nerve (sural) amplitude (SNAP) and latency (p<0.05) indicating significant axonal damage. The time taken to develop peripheral neuropathy was 4 Cycles with Grade 2/4. Conclusions: In this present study , the neurotoxicity induced by Carboplatin–Paclitaxel in patients with lung or ovarian carcinoma was observed. More effective dosing– schedules of treatment decreases the incidence of long lasting peripheral neurotoxicity thus providing better results withlonger survival rate and less disability.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

A STUDY ON CARBOPLATIN -PACLITAXEL INDUCED PERIPHERAL NEUROPATHY IN CANCER PATIENTS, Umamaheshwari.C, Shanthi.M INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-6 | June-2019

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