Volume : III, Issue : III, March - 2013

A trypsin inhibitor– SNTI with antidandruff activity from Sapindus trifoliatus

K. Vijaya Rachel, Y. Vimala, D. Apta Chaitanya

Abstract :

A trypsin inhibitor, designated Soap Nut Trypsin inhibitor (SNTI) with both antifungal and antibacterial activity exhibiting a molecular mass of 29kDa on SDS–polyacrylamide gel electrophoresis, was isolated from soap nut seeds (Sapindus trifoliatus L) by a combination of ammonium sulfate precipitation, ion exchange chromatography and gel permeation chromatography on Sephadex G–100. It exerted potent antifungal activity against dermatophytic fungi Trichophyton ruum and Malassezia furfur which are implicated in causing dandruff. SNTI exhibited antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Proteus vulgaris and Escherichia coli. The extracts of the pericarp which contained secondary metabolites also exhibited antifungal activity to a lesser extent compared to SNTI. The results obtained herein indicate that SNTI possess exploitable potentials for therapeutic applications.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

K. Vijaya Rachel,Y. Vimala,D. Apta Chaitanya A trypsin inhibitor- SNTI with antidandruff activity from Sapindus trifoliatus Indian Journal of Applied Research, Vol.III, Issue.III March 2013


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