Volume : X, Issue : VII, July - 2020

Antioxidant biochemical parameters in Parkinson's Disease in Libyan Population

Dr. Hatem Fawzi Gharour, Dr. M. L. Rajeswari, Dr. Andrew J Bennett, Dr. F. G. Dawoodi, Dr. Abdelhamid A Elzwawi, Dr. Abdelkarem A. S. Elgazali, Dr. Prajna Barke, Laxmi Teja Peela, Nischal Yedla, Sudheshna Sai Chanamallu, Dr. Peela Jagannadha Rao

Abstract :

Background: Parkinson’s disease PD is characterized by dopaminergic neuronal loss in the substantia nigra at the central nervous system (CNS), a significant reduction in dopamine levels, and the presence of Lewy bodies Lewy bodies are composed of abnormal deposits of protein aggregates, particularly synuclein proteins. While the main etiology of the disease has yet to be determined. Environmental, occupational and genetic factors seem to play important roles Risk factor studies have pinpointed age, gender, occupation, area of residence, smoking, coffee/tea consumption, drinking well–water, and being exposed to herbicides/pesticides. Biochemical studies designated to elucidate the underlying mechanism of P.D pathogenesis and also if there is any correlation between any of the biochemical parameters that might give a key for the association between the environmental and genetic study. Materials and Methods: Estimation of the levels of Nonenzymatic antioxidants: Vitamins, C, A, and E and Antioxidant Enzymes: Superoxide Dismutase (SOD) Glutathione peroxidase (GPX) and, Catalase (CAT).A total of 104 subjects, including control, were enrolled in the study and further grouped as 52 clinically examined Idiopathic Parkinson’s disease patients (35 males and 17 females) while remaining 52 were taken as age and sex–matched healthy controls. Results: The biochemical studies have shown that serum vitamin D concentration was lower among Parkinson’s disease cases and it was also associated with age, sex, marital status, education, leisure–time physical activity, smoking, alcohol consumption, body mass index, diabetes, hypertension, and the serum cholesterol. The RR of the disease between the highest and lowest quartiles of vitamin D concentration was 0.35 (95% CI 0.15–0.81, p for trend=0.006). In our study, there is a significant decrease in the activity of Glutathione peroxidase (p< 0.001), Superoxide dismutase (p< 0.001), and Catalase (p< 0.001) in PD patients as compared with controls. Further Vitamin C (p< 0.05),Vitamin E (p< 0.05) significantly decreased, but Vitamin A and Uric acid levels (p> 0.05) remain unchanged and this may be due to the compensatory mechanism of the body against oxidative stress, which not allowed much alteration in other parameters in the PD patients as compared with controls. We found statistically significant differences between cases and control regarding age, and gender (p = 0.04, and p = 0.01, resp.). Elevated homocysteine concentrations, homocysteine was 14.4 µmol/L in PD and 12.6µmol/L in controls (P>0.05). Additionally, there were no statistically significant differences in the levels of B12 and folic acid levels between cases as compared to control. The proportion of cases with coenzyme Q10 deficiency was also significantly greater in cases than in controls (32–36% vs. 8– 9%; P=0.0012–0.006). Conclusion: Present study concludes that all antioxidants both enzymatic and non enzymatic are showing lower activity in patients suffering from parkisnon’s disease. There is requirement to know the levels of albumin along with antioxidants.

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Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

ANTIOXIDANT BIOCHEMICAL PARAMETERS IN PARKINSON'S DISEASE IN LIBYAN POPULATION, Dr. Hatem fawzi Gharour, Dr. M.L.Rajeswari, Dr. Andrew J Bennett, Dr. F.G.Dawoodi, Dr. Abdelhamid A Elzwawi, Dr. Abdelkarem A. S. Elgazali, Dr. Prajna Barke, Laxmi Teja Peela, Nischal Yedla, Sudheshna Sai Chanamallu, Dr. Peela Jagannadha Rao INDIAN JOURNAL OF APPLIED RESEARCH : Volume-10 | Issue-7 | July-2020

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