Volume : IV, Issue : II, February - 2014

Antioxidant Role of Carnosine in Type–II Diabetic Wistar Rats

Ibrahim Alzahrani, Abdel Naser Badawy, Nermin El Morshedi

Abstract :

Background: Antioxidant effect of carnosine against metabolic disorders and oxidative stress in Streptozotocin diabetic-induced models was studied. Methods: Streptozotocin induced diabetes was done in male Wistar rats and low-density lipoprotein cholesterol, high density lipoprotein cholesterol and triacyglycerol, serum glucose and insulin analyzed weekly. At fourth week end, serum catalase, superoxide dismutase and glutathione levels were measured, accompanied by histopathological and immunohistochemical studies. Results: Diabetic rats showed significant increased levels of serum glucose, insulin, triacylglycerol and low density lipoprotein, but, high density lipoprotein was decreased. Antioxidant enzymes levels, tissue glutathione, superoxide dismutase and Catalase were decreased. Histopathological and immunohistochemical alterations were found. Carnosine induction, was effective in ameliorating serum glucose and insulin levels of diabetic animals and improving studied parameters of lipid profile and antioxidant enzymes activity. Also, recovery of histopathological and immunohistochemical alterations. Conclusion: These results suggest that carnosine may be used as potential multi-protective agent for diabetic complications . Abeviations: DM-II: Diabetes Mellitus type-II, HDL: high-density lipoprotein cholesterol, LDL: low-density lipoprotein cholesterol, TG: triacylglycerol, SOD: superoxide dismutase , GSH: glutathione , STZ : streptozotocin.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Ibrahim AlZahrani, Abdel-Naser Badawy, Nermin El-Morshedi Antioxidant Role of Carnosine in Type-II Diabetic Wistar Rats Indian Journal of Applied Research, Vol.IV, Issue. II

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