Association between serum ferritin and microalbuminuria in Type 2 Diadetes Mellitus.

Taranjeet Kour; Sanjay Bhat; Kalyan Dutt; Karan Dang

Volume : X, Issue : V, May - 2020

Association between serum ferritin and microalbuminuria in Type 2 Diadetes Mellitus.

Taranjeet Kour, Sanjay Bhat, Kalyan Dutt, Karan Dang

Abstract :

Aims and Ojective: To study the association between serum ferritin and microalbuminuria in Type 2 diabetes mellitus and their role as early markers of nephropathy. MATERIAL AND METHODS: A parallel randomized group study was conducted over a period of one year. One hundred patients of Type 2 diabetes mellitus ,on oral hypoglycemic agents or Insulin therapy or both without any previous history of cardiovascular/ renal/liver disease were enrolledto explore any association between serum ferritin and microalbuminuria. All patients after setinclusion /exclusion criteriawere subjected to thorough history using standard questionnaire,anthropometric measurements and routine investigations.Morning Spot urine albumin creatinine ratio for microalbuminuriaand serum ferritin levels were assayed. All the data was analyzed with the help of computer software SPSS version 17.0 and Epi–info version 6.0 for windows. Logistic regression was used to identify association between serum ferritin and microalbuminuria in Type 2 diabetes.The patients were divided into 4 quartiles based on serum ferritin levels and we found there were statistically significant differences between the four ferritin quartiles of all the studied variables of the entire cohort except the gender which showed non–significant differences. Results: In our study, 100 Type 2 diabetes mellitus patients (consisting 71 males and 29 females) with age group 45–65years (51.75±6.42) were evaluatedElevated serum ferritin was a strong and independent risk factor for microalbuminuria in patients with Type 2 diabetes. The microalbuminuria prevalence increases from (Q1) to (Q4). Compared with individuals in the lowest quartile, those in the fourth quartile were more likely to have microalbuminuria.Our study shows significant association with duration of diabetes mellitus, diastolic blood pressure and serum ferritin levels in patients with microalbuminuria. In the entire cohort, ferritin was significantly correlated with HbA1c (r = 0.33, p = < 0.001), fasting blood sugar (r = 0.29, p = < 0.001), random blood sugar (r = 0.34, p = < 0.001), urine albumin creatinine ratio (r = 0.50, p = <0.0001) and total leucocyte count (r = 0.28, p = <0.001) and C–reactive protein(r = 0.25, p = 0.03). Microalbuminuria was also found to be significantly correlated with HbA1c (r = 0.33, p = < 0.001), fasting blood sugar (r = 0.29, p = < 0.001), random blood sugar (r = 0.34, p = < 0.001), ferritin level (r = 0.50, p = <0.0001), total leucocyte count (r = 0.28, p = <0.001) and C–reactive protein(r = 0.25, p = 0.03). Conclusion: High serum ferritin is associated with a cluster of cardiovascular risks such as the metabolic syndrome, insulin resistance, obesity and elevated inflammatory markers. Microalbuminuria is also a manifestation of subclinical systemic inflammation, so it is understandable that high serum ferritin is associated with microalbuminuria and can serve as marker of early nephropathy were microalbuminuria can’t be estimated.