COMPARATIVE STUDY BETWEEN INTRAVENOUS GRANISETRON AND METOCLOPRAMIDE FOR THE PREVENTION OF EMESIS AFTER GYNAECOLOGICAL SURGERY UNDER SUBARACHNOID BLOCK

DR AnilKumar M R; DR PANKAJA R

Volume : V, Issue : XI, November - 2015

COMPARATIVE STUDY BETWEEN INTRAVENOUS GRANISETRON AND METOCLOPRAMIDE FOR THE PREVENTION OF EMESIS AFTER GYNAECOLOGICAL SURGERY UNDER SUBARACHNOID BLOCK

Dr Anilkumar M R, Dr Pankaja R

Abstract :

<p>&lt;p&gt;&amp;nbsp;Back ground and objectives Nausea and vomiting after spinal anaesthesia for gynaecological surgery are distressing to the patient. Granisetron, a selective 5&amp;ndash;HT3 antagonist, is more effective than the traditional antiemetic metoclopramide for the prevention of PONV. This study was undertaken to evaluate the efficacy and safety of granisetron, versus metoclopramide for the prevention of postoperative nausea and vomiting in patients undergoing major gynaecological surgery under subarachnoid block. Methods In this randomized, double&amp;ndash;blind study hundred patients (age, 20&amp;ndash;60 years) of ASA I&amp;ndash;II received intravenous Granisetron 1mg, Metoclopramide 10mg (n = 50 of each) immediately before induction of anaesthesia. Postoperatively the incidences of nausea, vomiting and safety assessments were performed at 1, 2, 6 and 24hour during the first 24 hour after surgery. Results There were no differences between the groups with regard to patient demographics. The percentage of patients who had complete response was 68% (34/50) with granisetron and 40% (20/50) with metoclopramide (P &amp;lt; 0.05); the corresponding rates at 1, 2, 6 and 24 hour after anaesthesia were 80 and 74%; 78 and 60%; 100 and 84% (P &amp;lt; 0.05); 100 and 98% respectively. Safety profiles of the two drugs were comparable, as no clinically serious adverse effects caused by study drugs were observed in either of the groups. Conclusion The prophylactic therapy with Granisetron is highly efficacious and safe than Metoclopramide in preventing PONV in patients undergoing gynaecological surgery under subarachnoid block.&lt;/p&gt;</p>