COMPARATIVE STUDY OF ZINC IN DIFFERENT DOSAGE AND DURATION IN MANAGEMENT OF ACUTE DIARRHOEA IN CHILDREN

Dr Kanwar Singh; Dr Giriraj Sharma; Dr Anil Jain; Dr Jaiprakash Narayan

Volume : VII, Issue : VI, June - 2017

COMPARATIVE STUDY OF ZINC IN DIFFERENT DOSAGE AND DURATION IN MANAGEMENT OF ACUTE DIARRHOEA IN CHILDREN

Dr Kanwar Singh, Dr Giriraj Sharma, Dr Anil Jain, Dr Jaiprakash Narayan

Abstract :

Aims: To study the effect of zinc therapy in different dosage and duration on stool frequency, total duration of diarrhoea and recurrence of acute diarrhoea. Settings and Design: This study is Prospective hospital based study done in the Department of Pediatrics, JLN medical college and hospital, Ajmer from January 2015 to September 2015(9 months) after ethical committee permission. Methods and Material: Patients of acute diarrhoea admitted in children ward of age group between 6 months to 5 years were included in the study. Patients with Chronic diarrhoea, Persistent diarrhoea, Dysentery and Diarrhoea with any associated co–morbidity like fever and respiratory distress were excluded from study. All cases enrolled in study were divided in five groups randomly from group A to E and all groups received low Osmolarity ORS. Group A have been given zinc 20 mg per day for 14 days, Group B zinc 20 mg per day for 10 days, Group C 10 mg for 14 days, Group D 10 mg per day for 10 days and Group E without zinc. Statistical analysis:– Mean, Standard deviation, F–test, Z–test and P–value were used Results: A 400 cases total were enrolled and during follow up 23 cases dropped out. Remaining 377 cases were taken among which 76(20.16%) in groupA, 78(20.69%) ingroupB, 72(19.10%)in group C, 74(19.63%)in group D, 77(20.42%) in group E. There is no significant difference in total stool frequency among various groups. P–value is 0.200(more than 0.05 is not significant. F–ratio is 1.504(less than 2.37 is not significant. There is no significant difference in total duration of diarrhea among various groups. F–value is 0.52(less than 2.37 is not significant. P–value is 0.725(more than 0.05 is not significant. There is significant difference in the reoccurrence of diarrhea among various groups. F–ratio is 3.39(more than 2.37 is significant). P–value is 0.00(less than 0.05 is significant. Conclusions: The study revealed no statistical difference in stool frequency and duration of diarrhoea in zinc v/s non zinc group. Though there was a short follow up of 3 months. This study clearly indicates significant differences in recurrence between zinc and non zinc group.