Comparison of efficacy of Propofol & Ketamine and Propofol & fentanyl in patients undergoing surgery.

Dr. Badri Narayana Chigullapally

Volume : VIII, Issue : XII, December - 2018

Comparison of efficacy of Propofol & Ketamine and Propofol & fentanyl in patients undergoing surgery.

Dr. Badri Narayana Chigullapally

Abstract :

Introduction: An ideal anaesthesia always provides pleasant induction, minimal adverse conditions, inevitable loss of consciousness and rapid, smooth recovery of protective reflexes. The combination of Propofol, Fentanyl and Ketamine provides complete and balanced anaesthesia with advantages such as high potency, lower doses and fewer side effects. This study designed to compare the efficacy of propofol with fentanyl and propofol in combination with ketamine in patients undergoing surgeries.

Materials and Methods: The present comparative study contains 120 cases undergoing various surgeries belonged to ASA grade I and II of both sexes and age between 2^nd to 6^th decades were recruited. Based on administered drug combinations cases were divided in to two groups i.e. group 1 administered with propofol & ketamine and group 2 administered with propofol and fentanyl. Oxygen saturation (SpO2), Heart rate, Systolic blood pressure (SBP), diastolic blood pressure (DBP) and respiratory rate was noted for all the participants before the surgical procedure and for every 5min after a surgical procedure.

Results: The onset of induction was rapid in group 1 cases than group 2 cases. The mean pulse rate was significantly decreased after induction at 1 min, 5 min, 10 min, and 20 min. whereas in group 2, the mean pulse rate was decreased at 1 min and increased at 5 min, 10 min and 20 min. The mean respiratory rate and oxygen saturation also stable in both groups.

Conclusion: The drug combination of propofol & ketamine and propofol & fentanyl are efficient in the maintenance of respiratory rate, oxygen saturation and haemodynamic stability. In this regard, drug combination of propofol & ketamine are best drug choice in surgical practice. Acceptance of propofol & ketamine is higher than propofol & Fentanyl.