Correlation of serum Malonialdehyde Acetylaldehyde  Adduct to serum Malondialdehyde as oxidative  stress markers in Acute Coronary Syndrome patients

Dr. Faisal Gh. Al-Rubaye

Volume : IV, Issue : VI, June - 2014

Correlation of serum Malonialdehyde Acetylaldehyde Adduct to serum Malondialdehyde as oxidative stress markers in Acute Coronary Syndrome patients

Dr. Faisal Gh. Al Rubaye

Abstract :

Background: Advances in our understanding of the pathophysiology of acute coronary syndrome (ACS) have led to the marked increase in development of new biomarkers for its diagnosis. One of these markers is a molecule, known as malondialdehyde–acetaldehyde or MAA also appeared to indicate the presence of coronary artery disease. Aim: to investigate the relationship between MAA–adducted proteins and parameters of oxidative stress on the one side and different types of acute coronary syndromes on the other.Subject and methods: the present study is a case–control study conducted during the period from April, 2004 till the end of December 2005, which includes measurement of serum malondialdehyde by chemical method and malondialdehyde–acetyl aldehyde by Enzyme Linked ImmunoSorbant method on 138 patients with Acute Coronary Syndrome attending the Cardiac Care Unit at Al–Kadhimiya Teaching Hospital with a matching group of 40 apparently volunteer subjects for age and sex which were considered as a control. Results: the serum (malondialdehyde & malondialdehyde–acetyl aldehyde) are significantly elevated in Acute Coronary Syndrome patients (Acute Myocardail Infarction and Unstable Angina) (P<0.001) as compared with controls; however, these parameters are not altered significantly (P>0.001) when patients groups are compared with each other. Both malondialdehyde & malondialdehyde–acetyl aldehyde are significantly correlated (r=0.9, P<0.001 in all study groups whether Acute Coronary Syndrome or control groups.In conclusion: all patients with coronary diseases have oxidative stress. This is supported by the finding of high serum (malondialdehyde & malondialdehyde–acetyl aldehyde ) which are markers of oxidative stress. Measurement of malondialdehyde–acetyl aldehyde protein adduct by many kits that are commercially available; as this adducts may be playing a role in the development and/or progression of vascular disease such as atherosclerosis, this biomarker is still under intense investigation and lack specificity