Cytotoxic Effects of Terminalia Chebula on Meiotic & Mitotic Chromosomes of Vicia Faba

Monika Asthana; Rakesh Kumar Sarbhoy; Surabhi Mahajan; Avnish Kumar

Volume : III, Issue : VII, July - 2014

Cytotoxic Effects of Terminalia Chebula on Meiotic & Mitotic Chromosomes of Vicia Faba

Monika Asthana, Rakesh Kumar Sarbhoy, Surabhi Mahajan, Avnish Kumar

Abstract :

There is known curative effect related to heart and digestion disorders by the fruits of Terminalia chebula irrespective of rationale dose. Here we showed effect of different concentrations (5, 10, 20, 30, 40, & 50%) of T. chebula extracts on meiotic and mitotic chromosomes of Vicia faba plant for 4 different time periods. Flower bud treatment method and root tip treatment methods were used for meiotic and mitotic analysis, respectively. Mitotic and meiotic chromosome indicated various abnormalities against higher doses. Cytotoxicity was inferred, Mitotic index of treated cells was significantly different (P<0.05) from control. The percent of abnormalities increase with increasing dose (5–50%) and time (4–24 hours). Stickiness was more frequent than other abnormalities. Higher dose was shown more cytotoxic effect; concluding Terminalia chebula extract could be toxic with injudicious dose.