Database Development on Inborn Errors of Nucleotide Metabolism in Homo Sapiens and Tool Designing for Nucleotide Sequence Alignment

Satyamvada Maurya; Mansaf Alam

Volume : III, Issue : VII, July - 2014

Database Development on Inborn Errors of Nucleotide Metabolism in Homo Sapiens and Tool Designing for Nucleotide Sequence Alignment

Satyamvada Maurya, Mansaf Alam

Abstract :

Inborn errors of metabolism (IEMs) are individually rare, but collectively numerous. Recently; IEMs were considered a specialty of pediatricians. Indeed, the term “inborn” has meant for a long time, a disease which starts in the newborn period or at least in childhood. Although most IEMs can have mild forms starting in adolescence or late in adulthood, this concept of “adult onset IEMs” has not reached the medical community until recently. They refer to single gene disorders where in loss of function of a single enzyme results in abnormalities in synthesis or catabolism of proteins, carbohydrates or fats, which results in a disruption in a metabolic pathway. In have developed a computational tool, for in born errors of nucleotide sequence alignment. This tool is based on the Dynamic Programming Algorithm. These data indicate the impartment of similarity, dissimilarity and evolutionary relationship to each other.