Volume : III, Issue : IX, September - 2013

Effects of Hyperthyroidism on Lipid Profile, Adiponectin and Liver Function Tests of Male Rats

Ghada Z A Soliman

Abstract :

Introduction: Thyroid hormone influences the function of all body organs and cells. Thyroid abnormalities are accompanied by changes in intermediary metabolism including alterations in body weight and lipid profile. Aim: to investigate the effect of hyperthyroidism on serum or plasma lipids profile, adiponectin and liver function tests as compared to controls. Materials and Methods: 40 rats weighing 220–250gm, divided into 2 groups (20 rats each). G1: control normal group; and G2: hyperthyroid rats group. Body weights were recorded on weekly bases. Serum or plasma FT3, FT4, TSH, total cholesterol (TC), low density lipoprotein cholesterol (LDL–C), high density lipoprotein cholesterol (HDL–C) triacylglycerols (TG), adiponectin, alanine and aspartate aminotransferase (ALT and AST) were measured using appropriate kits. Results and Discussion: Results reveals significant decreased level of TC, HDL–C, LDL–C, VLDL–C, and TG in hyper thyroid rats when compared with the normal control group. Also a significant increase in ALT and AST levels were found in hyper thyroid rats when compared with the normal control group. Hyperthyroidism was associated with a 51.75% increase in adiponectin (P< 0.0001). Adiponectin correlated with FT3 (r= 0.84, P< 0.0001) and FT4 (r= 0.96, P< 0.0001). Adiponectin was negatively correlated with TSH (r= 0.84, P< 0.0001), total cholesterol (r= –0.55, P< 0.0001), LDL–C (r= –0.46, P< 0.0001) and triacylglycerol (r = –0.38, P < 0.0001) in hyperthyroid rat group. Conclusion: Hyperthyroidism is associated with abnormal lipid profile, high adiponectin, urea and creatinine levels. This may be a possible explanation for the high cardiovascular morbidity among hyperthy¬roidic subjects. This study indicates that monitoring of lipid level in patients with thyroid dysfunction would be helpful in preventing cardiovascular diseases.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Ghada Z A Soliman Effects of Hyperthyroidism on Lipid Profile, Adiponectin and Liver Function Tests of Male Rats Indian Journal of Applied Research, Vol.III, Issue.IX September 2013


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