Volume : X, Issue : V, May - 2020

EFFICACY AND SAFETY STUDY OF INFLIXIMAB AND ETANERCEPT IN THE TREATMENT OF AXIAL SPONDYLOARTHRITIS

Gautam Mullick, Anuj Singhal, Vivek Hande

Abstract :

Spondyloarthritis (SpA) is a spectrum of enthesitis related autoimmune disorders comprising of axial and peripheral manifestations. The management of SpA is a step–wise approach wherein NSAIDs and Disease Modifying Anti–Rheumatic Drugs remain the first line therapy. Refractory cases and those with high disease activity are subjected to treatment with TNF blockers. In the present study we assess the efficacy of two such biological agents which have been the corner stone of TNF blocker therapy of SpA since times immemorial, viz. Infliximab (INF) and Etanercept (ETN). Data was collected from patients with SpA attending the Rheumatology outpatient department at the INHS Asvini Hospital, Mumbai, over 2 years between July 2016 and June 2018. SpA patients who were judged to be having therapeutic failure after adequate therapy with NSAIDs for at least 6 months were put on treatment with either ETN or INF. To monitor the disease activity, BASDAI (Bath AS Disease Activity Index) and ASDAS (AS Disease Activity Score) – ESR scores were recorded at baseline, and after 6 months and 12 months of therapy initiation. All data was recorded electronically and analyzed using SPSS v22; p<0.05 was considered to be statistically significant for all tests applied. Overall, the reduction in disease activity, as evidenced by reduction in the mean BASDAI and ASDAS–ESR scores over 12 months of treatment was statistically significant for all patients when considered together, as well as when ETN and INF were considered separately (p<0.0001 in all cases).

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Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

EFFICACY AND SAFETY STUDY OF INFLIXIMAB AND ETANERCEPT IN THE TREATMENT OF AXIAL SPONDYLOARTHRITIS, Gautam Mullick, Anuj Singhal, Vivek Hande INDIAN JOURNAL OF APPLIED RESEARCH : Volume-10 | Issue-5 | May-2020


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