Volume : IX, Issue : XI, November - 2019

Efficacy of oral Tadalafil in preoperative management of Adult Ostium Secundum Arterial Septal Defect Complicated with Pulmonary Arterial Hypertension

Dr. Santanu Dutta, Sanchita Das, Sumanta Ghosh, Dr. Shilpa Basu Roy

Abstract :

Purpose: To evaluate the efficacy and safety of oral tadalafil in reducing pulmonary arterial hypertension (PAH) in adult ostium secundum strial septal defect (OS–ASD) patients. Methods: Pre–operative patients with OSD complicated with PAH, age >18 years, were enrolled into two groups; Group A (oral tadalafil) and Group B (without tadalafil) for over a period of 3 months. Pulmonary artery pressure (PAP) at baseline and post three month of treatment was measured to evaluate the efficacy of tadalafil. Independent t–test and p–value were used to compare the various parameters between two groups. Safety was assessed as the incidence of adverse events (AEs) during the three month treatment period. Results: A statistically significant reduction in PAP from baseline was observed after completion of 3 months in patients receiving tadalafil (p=0.0004). On the contrary, an increase in PAP was observed in Group B patients not receiving tadalafil (from 41.86 ± 6.42 to 44.86 ± 5.33). Additionally, after three months of treatment, PAP between the two treatment groups was also statistically significant (p= 0.0006). No adverse events were associated with the use of oral tadafil. Conclusion: Oral tadalafil reduced pulmonary artery pressure in adult OS–ASD with PAH patients.

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Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

EFFICACY OF ORAL TADALAFIL IN PREOPERATIVE MANAGEMENT OF ADULT OSTIUM SECUNDUM ARTERIAL SEPTAL DEFECT COMPLICATED WITH PULMONARY ARTERIAL HYPERTENSION, Dr. Santanu Dutta, Sanchita Das, Sumanta Ghosh, Dr. Shilpa Basu Roy INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-11 | November-2019

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