Volume : III, Issue : VII, July - 2014

Evaluation of Immunoglobulins, Complement and Interleukine–6 in Serum of Iraqi Sepsis Neonates

Dr. Khetam Habeeb Rasool

Abstract :

Back ground: Limited information exists on immune response in Iraqi sepsis neonates. Objective: In this study, we have assessed the humoral immunesystem in 57 suspectedsepsis neonates by measuring their serum concentration of ImmunoglobulinG (IgG), IgM, IgA, C and C4in order to find out a responsible immunedefect in these patients in compares to control (healthy) neonates group .Interleukine–6(IL–6) was measured as marker for sepsis. Subjects and methods: blood was taken from (57)full term suspected septicemia neonates, classified into2 groups. A sepsis group (n = 22) and probable sepsis group (n = 35), andcontrol group(n=23). The parameters studied were: serum immunoglobulins (Ig) including IgA, IgG,IgM, the complement Components (C3, C4) levels were assessed using Single Radial Immunodiffusion (SRID) and IL–6 levels were determined using Enzyme Linked Immunossorbent assay (ELIZA) kit. Results: Serum levels of IgG, IgA, C3 and C4 were significantly lower (p≤0.01) and those of IgM and IL–6 were significantly higher (p≤0.01) in documented sepsis patients than the controls. Considering the result of analytic tests, it was revealed that,sepsis and probable sepsis patients had showed low IgG IgA,C3and C4 levels comber to control` group but no significant differences in IgG and IgAwas observed between sepsis group and probable sepsis group. Conclusion: The results of thisstudy points that IgM and IL–6 may be considered as an early diagnostic markers for sepsis andthe need for further research to clarify the role of dysfunction of immunoglobulins, complement systemin sepsis newborn infants and IL–6 correlation with the severity of the disease.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Khetam Habeeb Rasool Evaluation of Immunoglobulins, Complement and Interleukine-6 in Serum of Iraqi Sepsis Neonates Indian Journal of Applied Research, Vol.4, Issue.7 July 2014

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