Flupirtine for pre�emptive analgesia following laparoscopic gynaecological surgeries

Dr Sonal S.Khatavkar; Dr Amit Malik; Dr Anil Kumar; Dr Adithya Vishnu; Dr Shital Chaudhari

Volume : VI, Issue : VII, July - 2016

Flupirtine for pre�emptive analgesia following laparoscopic gynaecological surgeries

Dr Sonal S. Khatavkar, Dr Amit Malik, Dr Anil Kumar, Dr Adithya Vishnu, Dr Shital Chaudhari

Abstract :

<p>&nbsp;Aim: The aim of this study was to evaluate the efficacy of flupirtine, a NMDA receptor antagonist for postoperative analgesia when administered orally in patients undergoing gynaecological laparoscopic surgeries.Materials and Methods: Sixty adult female patients posted for laparoscopic gynaecological surgeries were randomly divided in to two groups to receive preoperatively either flupirtine or B complex orally as a placebo in a randomized double blind manner. Rest of the anesthetic management was same in both the groups. Pain/sedation scores, clinical parameters and side effects were studied and compared in both groups.The time to first dose of rescue analgesic and number of such rescue doses during first 24 hours postoperatively and patient&rsquo;s satisfaction were noted. Results: It was observed that mean time to first dose of rescue analgesic drug was 2 to 2.5 hours postoperatively in patients who received flupirtine preoperatively as compared to patients of placebo group who demanded first dose of analgesic almost immediately after surgery. This difference was statistically significant. Subsequently there was no difference between the two groups as regards pain and sedation scores as well as requirement of analgesia and incidence of side effects. Conclusions: Pre&ndash;emptive use of flupirtine provides adequate analgesia with mild sedation during immediate postoperative period after laparoscopic gynaecological surgeries and its use is devoid of any side effects.</p>