Volume : IV, Issue : II, February - 2014

Interleukin–1Beta and Tumor Necrosis Factor–Alpha Genes Polymorphism and Hepatocellular Carcinoma in Patients with Hepatitis C Virus in Egyptian Population

Interleukin 1beta And Tumor Necrosis Factor Alpha Genes Polymorphism And Hepatocellular Carcinoma In Patients With Hepatitis C Virus In Egyptian Population

Abstract :

Background: Hepatitis C virus (HCV) infection is a major risk factor for developing HCC. Cytokines are involved in various cancers. This work aimed to investigate the relationship between the gene polymorphisms of interleukin-1 beta (IL-1β), IL-1 receptor antagonist (IL-1RN) and tumor necrosis factor alpha (TNF-α) and the development HCV-related HCC. Methods: The study included 100 HCV patients (50 with HCC and 50 without HCC) and 70 apparently healthy individuals. Gene polymorphisms of IL-1β-31 C/T, IL-1β-511 C/T, IL-1RN variable number of tandem repeats (VNTR), and TNF-α-308 G/A were investigated by PCR based assay. Results: There were significant increase in the frequency of IL-1β-31 TT, IL-1RN A2A2 and TNF-α-308 AA genotypes in HCC group when compared to controls. There were, in addition, significant increase in the frequency of IL-1β-31 T, IL-1RN A2 and TNF-α-308 A alleles in HCC group when compared to controls. However, there was no significant difference in IL1β-511 gene polymorphism between different groups. Conclusion: HCV patients\' carriers for IL-1β-31 T, IL-1RN A2 or TNF-α-308 A alleles could be at risk of developing HCC.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Rizk El-Baz, Amr El-Rabat, Mohamed Abd El-Moneim, Ghada awadalla Interleukin-1Beta and Tumor Necrosis Factor-Alpha Genes Polymorphism and Hepatocellular Carcinoma in Patients with Hepatitis C Virus in Egyptian Population Indian Journal of Applied Research, Vol.IV, Issue. II


Number of Downloads : 998


References :