Meso Porous Silica Nanospheres For Delivery of Multikinase Inhibitor Sorafenib in Chemotherapy–an Invitro Study

Suma George; Dhanya Merin Stephen; Finosh G T; Rajesh Ramachandran

Volume : IV, Issue : VI, June - 2014

Meso Porous Silica Nanospheres For Delivery of Multikinase Inhibitor Sorafenib in Chemotherapy–an Invitro Study

Suma George, Dhanya Merin Stephen, Finosh G T, Rajesh Ramachandran

Abstract :

The major draw backs of chemotherapy includes mainly the poor solubility, specficity, stability of drugs and assisted delivery systems are found promising in overcoming this problem. Sorafenib, a class of novel multikinase inhibitors is being restircted to fewer pharmacological effects due to its poor solubility and pharmacokinetics. In the present study sorfenib was successfully loaded on mesoporous silica nanospheres with a loading efficiency of 93% and size of 396 nm. Cytotoxicity checking with normal fioblast cells shown increased toxicity of sorafenib alone over loaded form which can be attributed to specificity of drug release. The particles were found to induce cell death in HT 29 colorectal cancer cell lines in a dose dependent manner with IC 50 values of 50µg/ml. The results draw new insights in use of silica nanospheres as potent delivery systems for multikinase inhibitors