Volume : III, Issue : VII, July - 2014

Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms (C677T&A1298C) and risk of breast cancer among Egyptian women

El Shaimaa Shabana, Rizk El Baz, Mai El Shahat, Ali Ebrahem Shaltout, Abdel Aziz Fatouh

Abstract :

Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in the metabolism of folatea nutrient which has recently been found to be inversely related to east cancer. Two common variants in the MTHFR gene (C677T and A1298C) have been associated with a reduced activity of this enzyme, thereby increasing the availability of folate for thymidylate and purine synthesis. We investigated the relationship of these variants with invasive east cancer in a case–control study of 100 cases and 90 controls within this Study. We found an overall significant, inverse association between east cancer risk and the 677TT genotype and no association with the 1298C variant. The odds ratio [OR and 95% confidence interval (95% CI)] for the 677CC, 677CT, and 677TT genotypes were 1.00, 1.14 (0.6–2.08), and 5.5(1.5–20.3), respectively. Those for the 1298AA, 1298AC, and 1298CC genotypes were 1.00, 1.5 (0.7–3.01), and 2.005 (0.9–4.5), respectively. Elevation of east cancer risk was most pronounced among 677TT women who consumed the lowest levels of dietary folate 

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

El-Shaimaa Shabana, Rizk-El-Baz, Mai El-Shahat, Ali-Ebrahem shaltout, Abdel-Aziz fatouh Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms (C677T&A1298C) and risk of breast cancer among Egyptian women Indian Journal of Applied Research, Vol.4, Issue.7 July 2014

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