Volume : III, Issue : VII, July - 2013

Modification of Hyaluronic Acid with Hydrazine & Hydrazone; And Using their New Conjugates as Potential Antimicrobial Agents

E. Salah, R. Ahmed, E. Hala, B. Hala

Abstract :

Modification of the carboxylic acid moieties of hyaluronic acid (HA) with mono–functional hydrazine or hydrazone leads to biochemical probes, biopolymers with altered physical and chemical properties, tethered drugs for controlled release. Isonicotinyl hydrazine and benzophenone hydrazone were condensed with HA to produce conjugates (A) and (B). The reactions were activated by 2–(Benzotriazol–1–yl)–1,1,3,3–tetramethyluronium tetrafluroborate (TBTU). Both conjugates were characterized through 1 H NMR spectroscopy to indicate their formation and degree of substitution (SD). The antimicrobial tests of the conjugates indicated higher activity and long acting effect.

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

E. Salah, R. Ahmed, E. Hala, B. Hala Modification of Hyaluronic Acid with Hydrazine & Hydrazone; And Using their New Conjugates as Potential Antimicrobial Agents Indian Journal of Applied Research, Vol.III, Issue.VII July 2013


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