Normal CD4 & CD3 Lymphocyte Counts in Healthy  HIV Seronegative Adults in Tertiary Care Hospital  Vadodara, Gujarat, India.

Dr. Neelam Pandya; Dr. T. B. Javdekar; Dr. Payal Modi; Dr. Nishidh Pandya

Volume : I, Issue : II, October - 2012

Normal CD4 & CD3 Lymphocyte Counts in Healthy HIV Seronegative Adults in Tertiary Care Hospital Vadodara, Gujarat, India.

Dr. Neelam Pandya, Dr. T. B. Javdekar, Dr. Payal Modi, Dr. Nishidh Pandya

Abstract :

INTRODUCTION : The enumeration of CD4 and CD3 positive cells, surrogate markers for HIV disease progression, is helpful in management and follow up of immunocompromised HIV positive patients. In assessing the degree of immune deficiency in HIV–positive patients of a particular region, knowledge of reference range of T–cell subset counts of healthy individuals of that particular region is essential. OBJECTIVES : To determine the reference ranges of CD4 and CD3 counts in normal healthy adults and its variation in relation to age and sex. METHODOLOGY : This is a cross sectional study carried out in SSGH, at Microbiology Department, includes 185 healthy HIV seronegative Residents, Doctors and Health care workers of both sexes between the age 20–70 years over a period 3 years from August 2009 to August 2012. RESULTS : In our study Mean CD4 count 929.32 cells/µl which ranges between 887.76 – 970.89, cells/µl and Mean CD3 count is 1719.42 cells/µl which ranges from 1647.68 – 1791.16, cells/µl. INTERPRETATION : As there is heterogenicity in baseline CD4 T lymphocyte count of normal healthy adults , Our findings on T–cell subset reference ranges of normal healthy individuals validate the utility of determination of CD4 cell