Volume : IV, Issue : III, March - 2014

Numerical Modelling of Indomethacin Release from Pnipam– G �Peo Micellar Nanoparticles

Rumiana Blagoeva, Assen Nedev, Victoria Michailova

Abstract :

The object of the present paper is the Indomethacin (IMC) release from poly (N–isopropylacrylamide)–graftpoly (ethylene oxide) PNIPAM–g–PEO micellar nanoparticles (NPs). The release study was conducted in acetate and phosphate buffer solutions, pH 4.5 and pH 7.4, respectively, using the dialysis tube method. The nano–sized polymeric micelles were characterized with respect to morphology, drug loading content and in vitro drug release kinetics by Michailova et al. (2010). In the present paper this study was supported by an appropriate mathematical model and a numerical procedure for evaluation of the model parameters was validated under the obtained experimental data for two initial drugs loading at two different pH. The created numerical algorithm was used for simulation of IMC release within a period of 48 hours NPs, neglecting the presence of a memane.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Rumiana Blagoeva, Assen Nedev, Victoria Michailova Numerical Modelling of Indomethacin Release fromPnipam- G �Peo Micellar Nanoparticles Indian Journal of Applied Research, Vol.IV, Issue. III


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