PLASMID MEDIATED DRUG RESISTANCE IN ACINETOBACTER Baumanii ISOLATED FROM CLINICAL SAMPLES

Jayanthi.S; Renuka.B Jeya.M; Meena.N; Kurunchi C.Divya

Volume : V, Issue : V, May - 2015

PLASMID MEDIATED DRUG RESISTANCE IN ACINETOBACTER Baumanii ISOLATED FROM CLINICAL SAMPLES

Jayanthi. S, Renuka. B Jeya. M, Meena. N, Kurunchi C. Divya

Abstract :

&nbsp;Acinetobacter baumannii is a nosocomial pathogen of increasing importance. Prevalence of the multidrug&nbsp; resistant phenotype (MDR) Acinetobacter baumannii has increased during the last decade worldwide. Isolation, characterization of plasmids among resistant isolates are very important as they can be disseminated horizontally&nbsp; and contribute to global spread of resistance. Aim of the study to determine the antibiotic susceptibility of the isolates.&nbsp; Detection of plasmids from multidrug resistant A.baumanii by alkaline lysis method. A total of 107 clinically significant&nbsp; Acinetobacter species from clinical samples and plasmid extraction. A.baumanii from clinical samples were 73%, multidrug resistant isolates were 69.2% and plasmid extracted were 59.5%. Awareness of plasmid mediated drug resistant&nbsp; and molecular profiling of these strains are important in current era of drug resistance.