Volume : IX, Issue : VIII, August - 2019

Primary Fallopian Tube Carcinoma: A Review of A Single Institution Experience

Mukesh Sonkaria, R. K. Tanwar, Bharti Saxena, Nilima Soni

Abstract :

Background: Primary fallopian tube carcinoma (PFTC) is rare. Herein, we investigate the clinico– pathological characteristics and response to cytoreductive surgery & appropriate therapies for PFTC. Materials and Methods: A retrospective observational study of 5 women with a histopathologic diagnosis of PFTC from January 2004 to Dec 2018. Results: The mean age at diagnosis was 53 years (range, 46 to 62 years), and the mean follow–up period was 51 months. All (100%) patients were postmenopausal. Eighty percent had an ECOG score of 0–1.The most common clinical presentation was nonspecific pelvic pain (100%), followed by abnormal vaginal bleeding (80%), and adnexal mass of unknown origin (40%). Three (60%) patients were assumed preoperatively as primarily in the ovary. All patients were diagnosed postoperatively; Primary optimal cytoreductive surgery was achievable in 4/4 (100%) in advanced disease. Only 1 (20%) patient was in Stage IIA & four (80%) in Stage IIB – IIIB. The serous type histology was predominant (60%), 60 % were of grade 2 and 40% of high grade. All showed complete response (CR) to adjuvant paclitaxel and carboplatin (P+C).The mean progression–free survival (PFS) rate was 43.6 months and mean Overall survival (OS) was 51 months. Conclusion: PFTC is infrequently diagnosed preoperatively or intraoperatively due to its rarity, and has nonspecific presentation. Radical cytoreductive surgery, followed by postoperative adjuvant chemotherapy P+C is a standard treatment by which the survival potential of PFTC can be greatly enhanced.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

PRIMARY FALLOPIAN TUBE CARCINOMA: A REVIEW OF A SINGLE INSTITUTION EXPERIENCE, Mukesh Sonkaria, R. K. Tanwar, Bharti Saxena, Nilima Soni INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-8 | August-2019


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