PROSPECTIVE RANDOMIZED STUDY TO COMPARE CLONIDINE AND DEXMEDETOMIDINE FOR SEDATION IN MECHANICALLY VENTILATED PATIENTS

DR. SHAHEER AHMED SIDDIQUI; DR. ANIL GUPTA; DR. AMIT DAHIYA; DR. MEENAXI SHARMA

Volume : VI, Issue : VII, July - 2016

PROSPECTIVE RANDOMIZED STUDY TO COMPARE CLONIDINE AND DEXMEDETOMIDINE FOR SEDATION IN MECHANICALLY VENTILATED PATIENTS

Dr. Shaheer Ahmed Siddiqui, Dr. Anil Gupta, Dr. Amit Dahiya, Dr. Meenaxi Sharma

Abstract :

BACKGROUND: This prospective, randomized study was undertaken to compare Clonidine and Dexmedetomidine for sedation in mechanically ventilated patients. Materials and Methods: The patients were divided into two groups. Group A (n=40) patients received dexmedetomidine infusion started as a loading dose of 0.7mcg/kg over a period of 10 mins followed by maintenance of 0.2 Mcg/kg/hr with dosage titration up to 0.7mcg/ kg/hr. Group B (n=40) patients received clonidine infusion Sedation will be started with boluses in accordance with patient’s body weight 1mcg/kg/hr of clonidine with titration being achieved up to 2mcg/kg/hr with dosage increments to achieve a score of 4 in SAS. The level of consciousness will be evaluated using Riker Sedation–Agitation Scale. RESULTS: More patients in Group A were found to achieve the target sedation level (Mean RSAS–4 and 80.67% patients) than Group B (Mean RSAS– 4.25, 70% patients). The heart rate was found to be significantly lower in Group B than in Group A from 14 hours to 48 hours. The decrease in heart rate was also higher in Group B than Group A. The baseline hemodynamic parameters were comparable in both groups. The Mean Arterial Pressure was found to be significantly lower in Group B than Group A from 14 hours to 48 hours of the study. Hypotension occurred in 2 of the 40 patients in Group A (5%) and 14 of the 40 patients in Group B (35%). Conclusion: Dexmedetomidine is better drug in comparison to clonidine, as it provided better quality of sedation and hemodynamic stability