ROLE OF BLOOD UREA NITROGEN AS A MARKER IN EARLY PREDICTION OF SEVERITY IN ACUTE PANCREATITIS : AN INDIAN PERSPECTIVE.

VIVEK SAGAR PALLEPAGU; UMAMAHESWARA REDDY; K. PANDURANGARAO

Volume : VI, Issue : II, February - 2016

ROLE OF BLOOD UREA NITROGEN AS A MARKER IN EARLY PREDICTION OF SEVERITY IN ACUTE PANCREATITIS : AN INDIAN PERSPECTIVE.

Vivek Sagar Pallepagu, Umamaheswara Reddy, K. Pandurangarao

Abstract :

BACKGROUND: Severe Acute Pancreatitis (SAP) is a significant medical and surgical problem needs early identification and management. Current predictive scoring systems for assessing severity are difficult to practice and have important limitations. The aim of the study is to assess Blood Urea Nitrogen (BUN) as a marker of severity and single prognostic indicator with best discriminating value to identify patients at risk of SAP. METHODS: 36 patients with Acute Pancreatitis (AP) were admitted and BUN levels were determined. Bedside Index for Severity in Acute Pancreatitis criteria (BISAP) and RANSON’S score was used to assess disease severity and mortality. Receiver operator characteristic curves plotted and cutoff value was determined for the variable of interest. RESULTS: BUN at 24 hours has the best predictive value for SAP and for mortality with areas under the curve (AUC) of 0.992 (95% CI) and 0.961(95% CI) respectively with 24.17 as optimal cutoff. CONCLUSIONS: BUN serves as a simple, quick and accurate predictor of severity and mortality in AP have comparable predictive power with BISAP and RANSON’S score.