Volume : X, Issue : V, May - 2020

ROLE OF OXIDATIVE STRESS IN OUTCOME OF PERINATAL ASPHYXIA IN TERM NEONATES

Reetika Saini, Sarika Arora, Bc Koner, P. Lali, S. Ramji

Abstract :

BACKGROUND: Perinatal asphyxia (PA) may result in significant functional and biochemical changes due to hypoxia/ischemia of various organs. This study was done to evaluate the presence of oxidative stress in perinatal asphyxia and correlate it with outcome METHOD: This case–control study was conducted on 76 term neonates [38 cases with asphyxia and 38 controls]. Cord blood sample was collected from cases and controls. Another venous sample was collected after 48–72 hours from cases only. Serum Malondialdehyde (MDA) and serum Protein carbonyl (PC) levels were estimated in all samples. RESULTS: The median MDA levels of cases at birth were significantly higher in cases than in controls. The levels of MDA nearly doubled in cases at 48–72 hours (p<0.001). The median PC levels at birth were significantly higher in cases [as compared to controls (p<0.01). Increase in PC levels at 48–72 hours was not significant CONCLUSION: Oxidative stress may be responsible for multi–organ dysfunction in perinatal asphyxia which may be associated with adverse outcome

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Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

ROLE OF OXIDATIVE STRESS IN OUTCOME OF PERINATAL ASPHYXIA IN TERM NEONATES, Reetika Saini, Sarika Arora, BC Koner, P. Lali, S. Ramji INDIAN JOURNAL OF APPLIED RESEARCH : Volume-10 | Issue-5 | May-2020

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