Study of antibiotic resistance pattern among gram positive isolates of diabetic foot ulcer, with special reference to Methicillin resistance and inducible Clindamycin resistance

Dr Nazia Ahmad; Dr Sunanda Shrikhande

Volume : IX, Issue : V, May - 2019

Study of antibiotic resistance pattern among gram positive isolates of diabetic foot ulcer, with special reference to Methicillin resistance and inducible Clindamycin resistance

Dr Nazia Ahmad, Dr Sunanda Shrikhande

Abstract :

One of the important factors contributing to emergence of resistant strains in diabetic foot ulcers (DFUs) is inappropriate and widespread use of antimicrobials, either by patients themselves or primary care providers. So routine testing of antibiotic sensitivity plays a crucial role. Also routine test fails to detect Methicillin resistance (MR) which is mediated by mecA, encoding the PBP 2a and inducible Clindamycin resistance (ICR) due to erm genes. Hence, it is advisable to perform MR testing and D test for detection of inducible Clindamycin resistance routinely during the primary antibiotic testing for the knowledge of their prevalence and measures to be taken to control their spread. The present study included 212 diabetic foot ulcer patients, from which 94 (31.33%) gram positive isolates were obtained, of which 75 (25.0%) were Staphylococcus aureus, 9 (3.0%) were Coagulase negative Staphylococci (CoNS) and 10 (3.33%) were Enteroccocus species. Among the Staphylococcal isolates, Methicillin resistance was seen in 25.33% S. aureus and 33.33% CoNS species. Inducible Clindamycin resistance was seen in 20.0% S. aureus and 33.33% CoNS isolates